So the question is can you regenerate a knee that is completely worn out? The answer is, it depends... Many times people are told their knees are bone on bone when really that's not the problem. Often the cause of the pain is a meniscus tear and not arthritis, so you need to make sure you get the proper diagnosis. Unless you have had an MRI, then you cannot be certain of the problem. I like to place knee problems in 3 groups, 1. Arthritis/ Degeneration- These get the best results from my treatments 2. Meniscus Tears- These sometimes get good results from therapy 3. Ligament Tears- If a full tear they need surgery and if partial they may get good results.